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Global Rheumatoid Arthritis (RA) Market Analysis & Drug Forecasts, 2019-2029 – Late-Stage RA Pipeline Holds Promise But Likely Won’t Match the Utility of JAK Inhibitors

Dublin, Jan. 12, 2021 (GLOBE NEWSWIRE) — The “Rheumatoid Arthritis – Global Drug Forecast and Market Analysis to 2029” report has been added to’s offering. Global revenues from RA drug sales are expected to grow from $26.2B in 2019 to $29.1B in 2029.The publisher projects that the global RA marketplace – which, for the purposes of this report, comprises eight major pharmaceutical markets (8MM) (US, France, Germany, Italy, Spain, UK, Japan, and Australia) – will grow at a compound annual growth rate (CAGR) of 1.0% over the 10-year forecast. Global growth in the RA market will be driven by continued uptake of new products in the IL-6 and JAK inhibitor classes along with the anticipated approval and launch of four pipeline therapies. This growth will be slackened by sales erosion from biosimilars and generic tofacitinib. Over 70% of sales will come from the US; the US has a large population of RA patients (estimated 1.8M diagnosed prevalent cases in 2029) and high price tags for biologic and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs).Biosimilar erosion will temper the growth of the RA market during the forecast period; between 2019 and 2029, biosimilars sales will increase from 5% to 28% of global sales. Due to favorable local regulations and increased access, biosimilar uptake is expected to be the highest in the 5EU; by 2029, the publisher projects that biosimilar sales in 5EU will represent over 45% of its total sales -60% of which will come from sales of adalimumab and etanercept biosimilars. The publisher expects that despite biosimilar erosion, Pfizer/Amgen’s Enbrel and AbbVie’s Humira will remain the global sales leaders during the forecast period, amassing combined sales of $12.6B in 2019 and $9.0B in 2029. Sales of Enbrel and Humira are more likely to be protected from biosimilar erosion than Remicade (negative CAGR of 6.8%) mainly due to a lack of biosimilar availability in the US, the largest RA market in the 8MM. Etanercept and adalimumab biosimilars will not be available in the US until 2028 and 2023, respectively. Although biosimilars may temper the impact of blockbuster biologics, the publisher expects that the growth of the small molecule Janus kinase (JAK) inhibitor class will powerfully shape the RA market of the future. The publisher projects that the JAK inhibitor class will continue to grow significantly over the forecast period, increasing at a CAGR of 7.2%. This growth is expected to be strongest in the 5EU, where the first JAK inhibitors, Pfizer’s Xeljanz and Eli Lilly’s Olumiant, only became available starting in 2017. The recent global launch of AbbVie’s JAK1 inhibitor, Rinvoq, is expected to significantly expand JAK inhibitor market share, bringing in $2.2B in sales by 2029. The late-stage pipeline for RA consists of three subcutaneously delivered biologics (the TNF inhibitor ozoralizumab, the interleukin 6 [IL-6] inhibitor olokizumab, and the granulocyte-macrophage colony-stimulating factor [GM-CSF] inhibitor otilimab) and one oral kinase inhibitor (the BTK inhibitor fenebrutinib). Key opinion leaders (KOLs) expressed measured enthusiasm for these agents-they welcomed the potential availability of new mechanisms of action but did not think that any of them would be more or even equally effective as JAK inhibitors. Of these agents, KOLs were the most enthusiastic about GSK’s GM-CSF inhibitor, otilimab, expected to achieve global sales of $626.8M by 2029. All together, these four pipeline agents are expected to claim less than 5% of the RA market in 2029, equivalent to about $1.1B. Key Questions Answered With the increased entry of biosimilars into the RA marketplace, sales growth has begun to slacken and will likely continue to slow over the next 10 years.How will biosimilar uptake differ across the 8MM?What companies and drugs will be most affected by sales erosion from biosimilars?Although biosimilars may slow the growth of the RA market, the publisher expects that new agents in the JAK inhibitor class will powerfully shape the RA market going forward.What are the main R&D trends in the RA market and which companies are leading the way?Are there major differences in the mechanisms of action used by therapies in late-stage versus early-stage clinical development?KOLs interviewed by the publisher have indicated that there are still many remaining unmet needs within the RA indication.What are the main unmet needs in the RA market?How can the pharmaceutical industry address these needs?To what degree will the therapies under development fulfill these unmet needs? Key Highlights The greatest drivers of growth in the global RA market will be the continued uptake of new products in the IL-6 and JAK inhibitor classes, the anticipated approval and launch of four pipeline therapies, a steadily climbing diagnosed prevalence rate, and a high overall treatment rate.The main barriers to growth in the RA market will be significant market share erosion from biosimilars and tofacitinib generics as well as a challenging environment for new product launches due to intense competition in the market.KOLs expressed measured enthusiasm for the four pipeline agents in development. Of these agents, KOLs were most interested in the two with new mechanisms of action: GSK’s GM-CSF inhibitor, otilimab, and Roche/Genentech’s BTK inhibitor, fenebrutinib. Although they were dubious that these agents’ efficacy would be comparable to that of JAK inhibitors, they believed they would expand available options for patients and could potentially be useful in future combination regimens.The most important unmet needs in RA are those for earlier diagnosis and treatment, more cost-effective medications, personalized strategies for treatment of active disease, a better-defined approach to de-escalation of DMARDs during remission, as well as new options for patients with treatment-refractory disease. Scope Overview of RA including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.Topline RA therapeutics market revenue, annual cost of therapy, and major pipeline product sales in the forecast period.Key topics covered include current treatment and pipeline therapies, unmet needs and opportunities, and the drivers and barriers affecting RA therapeutics sales in the 8MM.Pipeline analysis: Comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of late-stage pipeline drugs.Analysis of the current and future market competition in the global RA therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications. Reasons to Buy Develop and design your in-licensing and out-licensing strategies, using a detailed overview of current pipeline products and technologies to identify companies with the most robust pipelines.Develop business strategies by understanding the trends shaping and driving the global RA therapeutics market.Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the global RA market in the future.Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.Track drug sales in the global RA therapeutics market from 2019-2029.Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships. Key Topics Covered: 1 Table of Contents1.1 List of Tables1.2 List of Figures2 Rheumatoid Arthritis: Executive Summary2.1 Biosimilar and Generic Erosion Will Stymie Sales Growth in the RA Market from 2019-20292.2 Development of Novel Oral Agents and Biosimilars Are Popular R&D Strategies2.3 Opportunities Remain for More Rapid, Targeted, and Cost-Effective Treatment for RA Patients2.4 Late-Stage RA Pipeline Holds Promise But Likely Won’t Match the Utility of JAK Inhibitors2.5 What Do Physicians Think?3 Introduction3.1 Catalyst3.2 Related Reports3.3 Upcoming Related Reports4 Disease Overview4.1 Etiology4.2 Pathophysiology4.3 Symptoms and Severity Classifications5 Epidemiology5.1 Risk Factors and Comorbidities5.2 Global and Historical Trends5.3 Forecast Methodology5.4 Epidemiological Forecast for RA (2019-2029)5.5 Discussion6 Disease Management6.1 Diagnosis and Treatment Overview6.2 US6.3 5EU6.4 Japan6.5 Australia7 Competitive Assessment7.1 Overview7.2 Biosimilars in the RA Market8 Unmet Needs and Opportunity Assessment8.1 Overview8.2 Earlier Diagnosis and Treatment8.3 Cost-Effective Therapies8.4 Personalized Treatment Strategies8.5 Improved Guidance on Treating RA Patients in Remission8.6 New Treatment Options for Patients with Refractory RA9 Pipeline Assessment9.1 Overview9.2 Promising Drugs in Clinical Development9.3 Other Drugs in Development – Kinase Inhibitors10. Current and Future Players10.1 Overview10.2 Trends in Corporate Strategy10.3 Company Portfolio Assessments11. Market Outlook11.1 Global Markets11.2 US11.3 5EU11.4 Japan11.5 Australia Companies Mentioned Abbvie IncAblynx NVAmgen IncAsahi Kasei Pharma CorpAstellas Pharma IncAstraZeneca PlcBiogen IncBristol-Myers Squibb CoCelltrion IncChugai Pharmaceutical Co LtdDaiichi Sankyo Co LtdEisai Co LtdEli Lilly and Co For more information about this report visit Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research. CONTACT:
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